Biohacking in aesthetics refers to combining evidence-based supplements and regenerative injectables to optimise skin health and treatment outcomes.
Combining Supplements & Injectables
Biohacking
The term biohacking has rapidly gained popularity across wellness, longevity, and aesthetic medicine circles. But as healthcare professionals, it’s important to pause and ask: what is biohacking, and how does it translate into safe, evidence-based clinical practice?
In its broadest sense, biohacking refers to the optimisation of biological processes to improve performance, longevity, and overall health. As outlined in mainstream medical resources such as WebMD, biohacking can range from lifestyle adjustments to more advanced biological interventions. However, in aesthetic medicine, the concept requires careful reframing.
For clinicians, biohacking is not about extreme experimentation. Instead, it represents a structured, science-led approach to combining supplements and injectable treatments to enhance skin quality, tissue regeneration, and long-term outcomes.
In 2026, this synergy between internal and injectable optimisation is becoming increasingly relevant for forward-thinking clinics.
The goal is not simply correction but optimisation
What Is Biohacking? A Clinical Definition
When patients ask, “what does biohacking mean?” or “what’s biohacking in aesthetics?”, the answer must remain grounded in evidence.
In a clinical context, biohacking can be defined as, a strategic approach to enhancing biological function using targeted interventions - including nutrition, supplementation, and regenerative treatments.
Rather than viewing injectables as standalone solutions, biohacking treatments encourage practitioners to consider systemic support alongside in-clinic procedures.
For aesthetic professionals, this means combining the following treatments.
Regenerative Injectables
Skin
Boosters
Microneedling Protocols
Evidence-based Supplementation
Lifestyle Optimisation
Why Biohacking Is Relevant to Aesthetic Medicine in 2026
The modern aesthetic patient is increasingly informed. Many are already exploring supplements, gut health, collagen powders, and longevity strategies. Clinics that ignore this trend risk appearing outdated.
However, there is a crucial difference between consumer-driven wellness culture and clinician-led optimisation.
In aesthetic medicine biohacking treatments must be:
Evidence-Informed
Ethically Delivered
Biologically Rational
Compliant with Regulatory Standards
By combining systemic nutritional support with regenerative injectables, practitioners can enhance tissue response, healing capacity, and longevity of results.
Injectables remain central to clinical biohacking strategies
The Injectable Side of Biohacking
Polynucleotides
Polynucleotides stimulate fibroblast activity, collagen synthesis, and extracellular matrix remodelling. When patients are nutritionally supported, the regenerative environment may be more favourable for tissue repair.
PRP (Platelet-Rich Plasma)
PRP leverages the patient’s own growth factors. Systemic micronutrient sufficiency may influence platelet quality and wound-healing capacity.
Exosomes
Exosome therapy supports intercellular communication and tissue regeneration. Combining exosomes with antioxidant and anti-inflammatory supplementation may support cellular resilience.
Skin Boosters
Hyaluronic acid skin boosters improve hydration and dermal support. Nutritional optimisation may complement barrier recovery and collagen maintenance.
These modalities represent structured, clinician-controlled biohacking treatments, not experimental interventions.
The Supplement Strategy: Internal Optimisation
To answer the question “what is biohacking in practical terms?”, we must consider internal factors.
Evidence-based supplementation may include:
- Vitamin D
Supporting immune modulation and skin health - Omega-3 fatty acids
Contributing to anti-inflammatory balance - Collagen peptides
Supporting connective tissue health - Antioxidants (Vitamin C, E, polyphenols)
Reducing oxidative stress - Barrier-support nutrients (zinc, ceramides)
Enhancing skin function
Importantly, supplementation should be framed as supportive - not therapeutic. Practitioners must avoid medical claims and ensure patients consult appropriately before beginning new regimens.
Combination Protocols: Where Biohacking Becomes Strategic
The most powerful aspect of clinical biohacking lies in structured combination protocols.
Supplements + Polynucleotides
Optimising micronutrient status before and during a course of polynucleotide treatment may support collagen synthesis and tissue regeneration.
PolyPhil
A widely adopted regenerative solution known for tissue bio-stimulation and skin repair support.
Plinest & Newest
Popular for delicate areas such as periocular rejuvenation & is Formulated for skin quality enhancement and anti-ageing support.
Pluryal
Combining polynucleotide technology with advanced formulation science.
Rejuran
Recently added to the Church Pharmacy portfolio, Rejuran has gained global recognition for skin rejuvenation and barrier restoration.
Supplements + Platelet-Rich Plasma (PRP)
Iron sufficiency, adequate protein intake, and antioxidant balance may support platelet function and healing response.
Supplements + Exosomes
Reducing systemic oxidative stress may create a more favourable cellular environment for regenerative signalling.
Supplements + Microneedling
Collagen co-factors (Vitamin C, amino acids) may support dermal remodelling following controlled injury.
Longevity, Inflammaging & Preventative Aesthetics
One of the strongest drivers behind biohacking trends is the concept of longevity.
Patients are no longer seeking short-term correction - they are investing in long-term tissue quality.
Chronic low-grade inflammation, often referred to as “inflammaging,” contributes to collagen breakdown, pigmentation changes, and barrier impairment. While injectables address structural components, systemic factors influence ongoing skin health.
Aesthetic biohacking acknowledges that:
Collagen decline is multifactorial
Oxidative stress impacts tissue integrity
Lifestyle affects recovery time
Internal inflammation influences visible ageing
For healthcare professionals, integrating this understanding strengthens consultation quality and patient education.
Protect patient trust and regulatory compliance
Managing Expectations & Compliance
Because biohacking is a broad and sometimes loosely used term, clinicians must maintain clarity. Here are some do's and don'ts when positioning biohacking treatments in your clinic.
The 2026 Clinic Model: From Correction to Optimisation
The next evolution in aesthetic practice is moving beyond “treat and repeat.”
The 2026 model is:
Assess systemic and lifestyle factors
Optimise where appropriate
Introduce regenerative injectables
Layer structural treatments
Maintain long-term tissue health
Clinics that integrate this approach may see improved patient retention, enhanced outcomes, and stronger differentiation in a competitive market.
Positioning Your Clinic
for the Biohacking Era
As aesthetic medicine evolves, patients are increasingly seeking optimisation rather than correction.
Clinics that understand how to combine internal support with advanced injectables will be well positioned for 2026 and beyond.
Church Pharmacy supports healthcare professionals with a comprehensive portfolio of regenerative injectables, PRP systems, skin boosters, supplements and clinical education - helping you integrate structured, compliant biohacking treatments into modern aesthetic practice.
About the author
Church Pharmacy
Church Pharmacy is a GPhC-registered UK pharmacy specialising in medical aesthetics. We support healthcare professionals with compliant dispensing, award-winning service, and expert insights into the latest treatments, products, and industry trends. Through our blog, we share practical guidance and trusted updates to help clinics grow safely, efficiently, and confidently.